Synthesis, Antioxidant and Antidiabetic Activity of 1-[(5-Substituted phenyl)-4,5-dihydro-1H-pyrazol-3-yl]- 5-phenyl-1H-tetrazole
نویسندگان
چکیده
N. KAUSHIK1*, N. KUMAR2, AND A. KUMAR3 School of Pharmaceutical Sciences, IFTM University, Moradabad–244102, 1School of Medical and Allied Sciences, Department of Pharmacy, Galgotias University, Greater Noida, Gautam Budh Nagar–201306, 2Oxford College of Pharmacy, UPSIDC, M-G Road, Ghaziabad–201001, 3Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Meerut–250005, India
منابع مشابه
Synthesis Analgesic, Anti-inflammatory and Antimicrobial Activities of Some 1-[5-(substituted Phenyl)-4,5-dihydro-1h- Pyrazol-3-yl]-5-phenyl-1h-tetrazole
Eight different derivatives of substituted 5-phenyl-1-(5-substituted phenyl) -4,5-dihydro1H-pyrazol-3-yl)-1H-tetrazole (4a-h) were synthesized by reacting the chalcones with hydrazine hydrate in presence of glacial acetic. The chemical structures were confirmed by means of FT-IR, H-NMR, mass spectra and elemental analysis. The compounds were screened for analgesic activity by acetic acid induce...
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New novel derivatives of N-((5-((6-oxido-6-(4 substituted phenoxy)-4,8-dihydro-1H-[1,3,2] dioxaphosphepino [5,6-c]pyrazol-1-yl) methyl)-1,3,4-thiadiazol-2-yl)carbamoyl) substituted benzene sulfo namides (7a-o as depicted in scheme) were Synthesized by condensation reaction of 4substituted Phenyl phosphorodichloridates (6a-c) and N-((5-((4,5-bis(hydroxymethyl)-1H-pyrazol-1-yi)methyl)1,3,4-thiadi...
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Reaction of 5-phenyl tetrazole with ethyl chloroacetate to form ethyl (5-phenyl-1H-tetrazol-1-yl) acetate (1). Compound 1 react with hydrazine hydrate in ethanol yield 2-(5-phenyl-1H-tetrazol-1-yl) acetohydrazide (2). The condensation of (2) with various aldehydes yield the corresponding substituted N'-[-arylidene]-2-(5-phenyl-1H-tetrazol-1-yl) acetohydrazide (3a- j). Th...
متن کاملDesign, Synthesis, Characterization and Biological Evaluation of Some Novel 1, 5 Disubstituted Tetrazole as Potential Anti-inflammatory Agents
In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro anti-inflammatory activity of various 1-[5-(substituted phenyl)-1-phenyl-4,5dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole (IV a-h).The anti-inflammatory activity of title compounds were examined by denaturation of proteins method. All the compounds exhibited weak to potent anti-inflammatory act...
متن کاملN-(4-Nitrophenyl)-2-{2-[3-(4-chlorophenyl)-5-[4- (propan-2-yl)phenyl]-4,5-dihydro-1H-pyrazol-1-yl]- 4-oxo-4,5-dihydro-1,3-thiazol-5-yl}acetamide
In the present investigation, the synthesis and spectroscopic characterization of N-(4-nitrophenyl)-2-{2-[3-(4-chlorophenyl)-5-[4-(propan-2-yl)phenyl]-4,5-dihydro-1H-pyrazol-1-yl]-4oxo-4,5-dihydro-1,3-thiazol-5-yl}acetamide (2) is performed. The title compound (2) is synthesized by the reaction of 3-(4-chlorophenyl)-5-[4-(propan-2-yl)phenyl]-4,5-dihydro-1H-pyrazole-1carbothioamide (1) with N-(4...
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تاریخ انتشار 2016